​Cancer Stem Cell​

Team Lead: Dr ​El-Nasir​ La​lani​​​, Professor Emeritus, AKU-CRM​​​

​​Our cancer stem cell team has generated two primary cancer cell lines with potential stem cell-like characteristics from metaplastic carcinoma of the breast, a rare aggressive form of breast cancer; and ​multiple myeloma, a type of blood cancer. These are amongst the first primary cancer cell lines to be developed in Pakistan under the supervision of Professor El-Nasir Lalani.

​The team is now planning to work​ on identifying:

  • The role of androgen receptor in the development an​d spreading of breast cancer, specifically triple-negative breast cancer​, and​ 

  • ​The function of Epstein-Barr, a virus that can cause tumours, and a protein called MUC1 in the development of multiple myeloma. ​

​​​

​D​r Nazia Riaz is leading the work on br​east cancer while Dr Sheerien ​Rajput is in charge of the research on multiple myeloma.​​

Rajput S, Minhas K, & Lalani ​E-N. (2019). Establishment and Characterisation of ​​a Myeloma Cell Line- AKU-MY01. Blood, 134(Supplement_1), 5535-5535. doi:10.1182/blood-2019-132238​

             
Rajput S, Minhas K, ​Azam I, Shaikh U, Hussain A, & Lalani E-N. (2019). LMP1 Expression in Bo​​ne Marrow Trephines of Patients With Multiple Myeloma Confers a Survival Advantage​. Leuk Lymphoma, 60(8), 1991-2001. doi:10.1080/10428194.2018.1563697.​​  
             
​Riaz N, Idrees R, Habib S, Azam I, & Lalan​i​ E-N. Expr​ession of Androgen Receptor and Cancer Stem Cell Markers (CD44+/CD24- and ALDH+): Prognostic Implications in Invasive Breast Cancer​.​ Translational Oncology. 2018. (doi: 10.1016/j.tranon.2018.05.002)​​ ​​
             

​​Team Lead​

Dr ​El-Nasir La​lani​​​

Professor Emeritus,​ AKU-CRM

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 ​hpicon_voice_calling1.pngelnasir.lalani@aku.edu​

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